1. 镇静剂;安眠药Downers are drugs that make you feel sleepy or very calm.
e.g. She was taking uppers and downers at the time.她那时在服用兴奋剂和抑制剂。
2. 令人悲伤(或沮丧)的情景If you describe a situation as a downer, you think that it is very depressing.
e.g. For divorced people, Christmas can be a downer.对离异的人来说，圣诞节令人感伤。